TNS Advanced+ Serum — (Real Pro Insight!)
After years working closely in the skincare industry, I can confidently say that SkinMedica’s TNS Advanced+ Serum is one of the very few luxury skincare products that actually delivers — when used correctly.
I’ve repurchased it many times because it continues to show results that nothing else quite matches — even though the nearly $300 price tag still makes me flinch every time.
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Performance:
This Advanced+ version is a serious upgrade from the original TNS Essential Serum.
It improves:
• Fine lines and wrinkles (especially around the eyes and mouth)
• Skin texture (feels smoother and more resilient)
• Firmness and elasticity (subtle lift effect)
• Tone and overall radiance (especially after consistent use)
The texture is much lighter and absorbs faster than the old TNS Essential Serum, without feeling greasy or sticky. It layers beautifully with other treatments — essential if you have a complex routine like I do.
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Key Ingredients (Deep Dive):
• TNS-MR (Growth Factor Blend): Over 450 growth factors and cytokines that help stimulate skin regeneration and repair visible signs of aging.
• Renessensce (RSC) Advanced: A blend of botanicals and peptides that support cell renewal and longevity.
• Hydrolyzed Silk, Peptides, and Polysaccharides: Smooth and hydrate the skin, giving an instant soft feel while working deeper over time.
• Antioxidant-rich extracts: Help combat environmental aggressors and oxidative stress.
Potential Concerns to Know:
• Contains fragrance — it’s minimal and generally tolerable, but still there.
• Silicones (Dimethicone) — present for smoother application but can bother acne-prone skin types.
• Human fibroblast conditioned media — effective but not vegan.
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The Price Reality:
At almost $300 a bottle, it’s a major investment. You’re not just paying for ingredients — you’re paying for decades of research, patented technologies, and clinical trials that back its claims.
That said, there are ways to build a routine around less expensive supporting products so you don’t break the bank (and yes — I’ll be sharing exactly how soon, stay tuned!).
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Best Dupe/Alternative (if you’re not ready for $300):
• Neocutis BIO•SERUM Firm Rejuvenating Growth Factor and Peptide Treatment
It’s another clinical-grade growth factor formula, highly effective, and often runs $100+ cheaper than TNS Advanced+ while still delivering excellent results over time.
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Important SkinMedica Note:
Out of all SkinMedica products, only two stand head and shoulders above the rest in my professional opinion:
• TNS Advanced+ Serum
• AHA/BHA Exfoliating Cleanser
Everything else? It’s either overpriced, over-fragranced, or underwhelming compared to newer technologies you can find elsewhere.
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Final Verdict:
• TNS Advanced+ works — for smoothing, firming, and rejuvenating the skin.
• Crazy expensive — but it’s legitimately one of the best growth factor serums available.
• Not a miracle in a bottle — best results happen when you build it into a strong, layered skincare routine (and yes, I’ll be sharing mine soon).
• Great for aging skin, texture concerns, and anyone serious about long-term skin health.
I will absolutely continue buying this until something even better comes along.
Like and follow me here on Amazon if you want real, tested skin advice — including how to layer smarter, when to splurge, and when to save!
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This item: SkinMedica TNS Advanced+ Serum - Our Premium Facial Skin Care Product, the Secret to Flawless Skin. Age-Defying Face Serum for Women is Proven to Address Wrinkles and Fine Lines for Glowing Skin,1 Oz
$295.00 ($295.00/ounce)
Get it as soon as Tuesday, May 13
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$48.00 ($8.00/fluid ounce)
Get it as soon as Tuesday, May 13
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$48.00 ($24.00/ounce)
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From the brand
TNS Advanced+ Serum
Next-generation, skin rejuvenating formula.
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SkinMedica was founded by pioneers in the science of skin rejuvenation. Our co-founder, the renowned dermatologist Dr. Richard Fitzpatrick, had a vision to develop a better way to slow the aging process and unlock the potential of the skin to heal from within; and in 1999, the groundbreaking scientifically based skin care line called SkinMedica was born.
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Improve Your Skins Appearance
Improves the appearance of coarse wrinkles, fine lines, skin tone, and texture.
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Two-Chamber System
Our key to our next-generation serum, can be found in our two chamber system.
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TNS Collection
From the manufacturer
The SkinMedica Method
 AHA/BHA Cleanser |  TNS Advanced+ Serum |  Even & Correct Serum |  HA5 Hydra Collagen |  Essential Defense SPF 47 | |
|---|---|---|---|---|---|
|
Customer Reviews
|
2,302
|
836
|
71
|
19
|
1,457
|
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Price
| $48.00 | $295.00 | — | $192.00 | $40.00 |
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Routine Step
| 1 - The Cleanse Factor | 2 - The Growth Factor | 3 - The Correct Factor | 4 - The Hydrate Factor | 5 - The Protect Factor |
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Benefits
| Gently exfoliates dead skin | Smooths wrinkles & fine lines | Brightens dark spots & melasma | Hydrates & restores | Protect against UVA/UVB rays |
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Key Ingredients
| Salicylic acid, jojoba oil | Growth factor blend, peptides | Tranexamic acid, niacinamide | 5 types of Hyaluronic Acid | Zinc oxide |
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Ideal For
| All skin types | All skin types | All skin types | All skin types | All skin types |
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Professional-grade skincare
| ✔ | ✔ | ✔ | ✔ | ✔ |
ADDICTED to Skin Medica
I have been using Skin Medica products for 17+ years. The TNS is an Incredible skin cream. When you first start using it, you’ll notice a little redness on your forehead - forget it. It’ll go away. I stopped using it after six months in the beginning just to see if there was a difference in my skin. There was a total difference! I needed more moisturizer. My skin felt dry, the texture looked different and my skin looked dull.. I see that people have problems with the pump. Just shake it or turn it upside down for a little bit and it’ll start coming back out again. As for the price, it takes a year to get rid of this product, using it twice a day religiously. It only takes one pump to cover your whole face and I also do my neck. I usually go brush my teeth to give it a chance to soak in before I put on my moisturizer. I just turned 73 and there is no one who thinks I am even close to my age….I am addicted! This pic is out of the shower, no makeup, no touch up.
Top reviews from the United States
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- Reviewed in the United States on April 29, 2025
- Reviewed in the United States on November 26, 2024
- Reviewed in the United States on March 16, 2025
I have been using Skin Medica products for 17+ years. The TNS is an Incredible skin cream. When you first start using it, you’ll notice a little redness on your forehead - forget it. It’ll go away.
I stopped using it after six months in the beginning just to see if there was a difference in my skin. There was a total difference! I needed more moisturizer. My skin felt dry, the texture looked different and my skin looked dull..
I see that people have problems with the pump. Just shake it or turn it upside down for a little bit and it’ll start coming back out again.
As for the price, it takes a year to get rid of this product, using it twice a day religiously. It only takes one pump to cover your whole face and I also do my neck. I usually go brush my teeth to give it a chance to soak in before I put on my moisturizer.
I just turned 73 and there is no one who thinks I am even close to my age….I am addicted!
This pic is out of the shower, no makeup, no touch up.
Images in this review
- Reviewed in the United States on March 22, 2025
Top reviews from other countries
- ELimReviewed in Singapore on August 29, 2024
Not both the chambers are able to pump
- Deborah WalkerReviewed in Canada on October 4, 2024
Guaranteed delivery date honoured by Amazon
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