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Microbiome Labs MegaSporeBiotic Probiotics for Women & Men - Spore Based Probiotics for Digestive Health - Shelf Stable & Travel-Friendly (60 Capsules)
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Brand | Microbiome Labs |
Flavor | Unflavoured |
Primary Supplement Type | Spore Based Probiotic |
Unit Count | 60 Count |
Item Form | Capsule |
Item Weight | 0.05 Kilograms |
Item dimensions L x W x H | 1.75 x 1.75 x 4 inches |
Special Ingredients | 5 Bacillus Spores |
Diet Type | Gluten Free |
Product Benefits | Gut Microbiome Support |
About this item
- 100% Spore-Based Probiotics - Our probiotic nutritional supplements can help support normal gut health by effectively reconditioning the gut. The spore based probiotic formula promotes microbial diversity and the maintenance of key health-promoting, commensal gut flora.*
- DNA-Verified Bacillus Strains - Includes bacillus subtilis, bacillus indicus, bacillus subtilis, bacillus licheniformis, bacillus clausii and bacillus coagulans probiotics for digestive health. We suggest starting with 1/2 a capsule or 1 full capsule with food and slowly increasing to 2 probiotic capsules per day, or as directed by your healthcare practitioner.
- Survives Digestion - The bi-phasic life cycle of the bacillus probiotics allows them to remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing to support daily gut health for women and men.*
- No Refrigeration Required - Spore-based digestive probiotic formulas can withstand a wide range of temperatures and are a travel-friendly option for the whole family. Probiotics for women, men, teens, and children age 5 and up.
- Science You Can Trust - We created the category of spore-based probiotics, and are backed by the biotech world leader Novozymes OneHealth. When creating our men's and women's probiotics for gut health, we control every step of our innovation and formulation process, from strain discovery to final product.
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Spore Based Probiotics
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Product Description





Combine with Customer Favorite Microbiome Labs Products
![]() MegaSporeBiotic | ![]() MegaSporeBiotic Gummies | ![]() MegaPre | ![]() MegaMucosa | ![]() Total Gut Restoration | ![]() FidoSpore | |
---|---|---|---|---|---|---|
Customer Reviews
|
4.6 out of 5 stars 3,029
|
4.6 out of 5 stars 3,029
|
4.7 out of 5 stars 56
|
4.2 out of 5 stars 194
|
4.6 out of 5 stars 3
|
4.3 out of 5 stars 74
|
Price
| $64.99$64.99 | $26.10$26.10 | $71.39$71.39 | $71.39$71.39 | — | $53.95$53.95 |
Product
| Spore-Based Probiotic | Spore-Based Probiotic | Prebiotic | Gut Mucosa Support | 4-Piece Kit | Dog + Cat Probiotic |
Form
| Capsules | Gummies | Powder | Powder | Capsules + Powder | Capsules |
Benefits
| Gut, Immune, Antioxidant | Gut, Immune, Antioxidant | Enhances probiotic benefits* | Supports healthy gut lining* | Comprehensive gut support* | Digestive support* |
Key Ingredients
| 5 Bacillus Spores | 4 Bacillus Spores | Clinically tested prebiotics | Aminos, Immunoglobulins | Probiotic, MegaPre, MegaMucosa | Probiotic, Beef Liver |
Practitioner Trusted
| ✔ | ✔ | ✔ | ✔ | ✔ | ✔ |
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 1.75 x 1.75 x 4 inches; 1.76 ounces
- Date First Available : June 25, 2019
- Manufacturer : Microbiome Labs
- ASIN : B07TJ4TH8Q
- Best Sellers Rank: #1,798 in Health & Household (See Top 100 in Health & Household)
- Customer Reviews:
Videos
Videos for this product
1:10
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WATCH BEFORE TRYING: How This Probiotic Effected Me
Scott Morrison
Videos for this product
0:09
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Customer Review: Not the bottle on picture.
Miriam Gonzalez
Videos for this product
1:19
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What makes this probiotic worth it?
lovinglifeathome
Videos for this product
0:50
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Microbiome Labs MegaSporeBiotic | Is It Worth the Hype?
Isabelle Weber
Videos for this product
0:30
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The BEST Probiotic for My Kids with Results!
Classic Southern Mom
Videos for this product
1:49
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Honest Review of this MegaSporeBiotic
🎯 We Actually Use This Stuff
Videos for this product
1:00
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Watch before you buy! A must-have probiotic.
Drew’s Reviews
Videos for this product
1:14
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MEGA Sporebiotic Gummies | Great For Kids & Pill Haters
Team Kandy
Videos for this product
0:19
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Why i LOVE this probiotic!
Serina’s healthy lifestyle must haves
Important information
Safety Information
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Please consult your healthcare professional prior to use, especially if you have or suspect a medical condition, have any allergies, are taking any prescriptions, or are pregnant or lactating.
Ingredients
Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans (SC-208), Bacillus licheniformis (SL-307), Bacillus clausii (SC-109), Cellulose, Vegetable Capsule.
Directions
Suggested Use: Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol.
Legal Disclaimer
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers report that the probiotic supplement works well for gut health, helping with digestive issues and chronic constipation. The product receives positive feedback for its quality, with one customer noting it strengthens gut microbiome, and customers find it tastes great. While some customers consider it good value, others say it's not worth the price. Several customers experienced stomach pain, including nausea and severe cramping.
AI-generated from the text of customer reviews
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Customers find that the probiotic supplement works well for good gut health.
"...I have been taking them for over a year and they never fail. Being able to order them on Amazon makes it easy. The price is good too." Read more
"...Spore probiotics, being hardier and able to survive the voyage through your gut, require a more watchful approach...." Read more
"great product" Read more
"Good quality. Work well." Read more
Customers report positive effects on gut health, noting improvements in digestive issues and chronic constipation.
"...market- it's spore-based, meaning it will get past your gut and into your colon! Yay! I notice a huge difference between this probiotic and others...." Read more
"...suggested this particular product to help me attain and maintain a healthy gut." Read more
"...Spore probiotics, being hardier and able to survive the voyage through your gut, require a more watchful approach...." Read more
"My toddler loves these and they really helped keep his belly happy when on antibiotics!" Read more
Customers praise this probiotic supplement for its effectiveness in strengthening gut microbiome, with one customer noting how it replaces unhealthy bacteria with beneficial ones.
"The best probiotic on the market- it's spore-based, meaning it will get past your gut and into your colon! Yay!..." Read more
"Fantastic probiotic recomended by my clinical nutritious. I have been taking them for over a year and they never fail...." Read more
"The best probiotic I've ever used. My doctor suggested this particular product to help me attain and maintain a healthy gut." Read more
"great product if you travel allot. Using a refrigerated pro-biotic is always best." Read more
Customers like the taste of these probiotics.
"...There isn’t any weird taste to these so don’t worry about that. Read the bottle as you need to increase the amount per week." Read more
"My homeopathic dr recommended this brand for my daughter, she really likes the taste and hopefully it’s helping!" Read more
"...The worst part was developing food intolerances I've never had before which probiotics are supposed to help with, not create...." Read more
"Love these probiotics. Most effective strains and easy to swallow, no taste." Read more
Customers have mixed opinions about the probiotic supplement's value for money, with some finding it good value while others say it's not worth the price.
"...My kids all take them daily! It is a bit more expensive, but you get what you pay for with probotics!..." Read more
"...Being able to order them on Amazon makes it easy. The price is good too." Read more
"Good probiotic! A little pricey but very good!" Read more
"...and the exorbitant cost! They quote the price per capsule (unit) but this is meaningless because..." Read more
Customers report experiencing stomach issues with this probiotic supplement, including nausea, severe cramping, and constipation.
"...Then I took one more and same symptoms of die off that felt like food poisoning, so I stopped completely...." Read more
"...but this time when I took it I had horrible days with stomach cramps and diaherra ...." Read more
"...I took one full pill with dinner and the next morning I felt nauseous and low energy. I went to the use the bathroom FIVE TIMES!!!..." Read more
"...After a week, the detrimental side effects were so bad that I had to discontinue use...." Read more
Reviews with images

Amazing and powerful probiotic 👍
Top reviews from the United States
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- Reviewed in the United States on January 29, 2025Size: 180 Count (Pack of 1)Style: CapsulesVerified PurchaseThe best probiotic on the market- it's spore-based, meaning it will get past your gut and into your colon! Yay! I notice a huge difference between this probiotic and others. My kids all take them daily! It is a bit more expensive, but you get what you pay for with probotics! I have major stomach issues and this is a must daily for me! If your diet is horrible follow the directions and start slow.
- Reviewed in the United States on March 29, 2025Size: 180 Count (Pack of 1)Style: CapsulesVerified PurchaseFantastic probiotic recomended by my clinical nutritious. I have been taking them for over a year and they never fail. Being able to order them on Amazon makes it easy. The price is good too.
- Reviewed in the United States on March 28, 2025Size: 60 Count (Pack of 1)Style: CapsulesVerified PurchaseThe best probiotic I've ever used. My doctor suggested this particular product to help me attain and maintain a healthy gut.
- Reviewed in the United States on January 28, 2025Size: 180 Count (Pack of 1)Style: CapsulesVerified PurchaseI discovered this type of probiotic while reading Dr. Izabella Wentz's book.
Although I had tried many probiotics before, I had never heard of spore-based probiotics.
I started with half a capsule on the first and second days, then increased to one capsule on the third and fourth days, gradually building up until I reached two capsules—one in the morning and one in the evening.
I've purchased it multiple times, but to be honest, I live a very healthy lifestyle. I don't consume gluten, sweets, or any processed foods at all.
Because of this, I didn’t experience any unusual reactions in my gut initially, as I don’t suffer from bacterial overgrowth. I really liked the product, and now I’ve started giving it to my husband using the same gradual approach, and he says it has helped him.
I am not a doctor; I’m a reader with a strong passion for functional medicine. I want to mention that for those who struggle to tolerate probiotics, they might want to look into postbiotics or Tributyrin (a component used in some postbiotics). I believe this suits most people, especially those with ulcerative colitis, Crohn's, or intestinal inflammation.
5.0 out of 5 starsI discovered this type of probiotic while reading Dr. Izabella Wentz's book.Amazing and powerful probiotic 👍
Reviewed in the United States on January 28, 2025
Although I had tried many probiotics before, I had never heard of spore-based probiotics.
I started with half a capsule on the first and second days, then increased to one capsule on the third and fourth days, gradually building up until I reached two capsules—one in the morning and one in the evening.
I've purchased it multiple times, but to be honest, I live a very healthy lifestyle. I don't consume gluten, sweets, or any processed foods at all.
Because of this, I didn’t experience any unusual reactions in my gut initially, as I don’t suffer from bacterial overgrowth. I really liked the product, and now I’ve started giving it to my husband using the same gradual approach, and he says it has helped him.
I am not a doctor; I’m a reader with a strong passion for functional medicine. I want to mention that for those who struggle to tolerate probiotics, they might want to look into postbiotics or Tributyrin (a component used in some postbiotics). I believe this suits most people, especially those with ulcerative colitis, Crohn's, or intestinal inflammation.
Images in this review
- Reviewed in the United States on December 16, 2023Size: 60 Count (Pack of 1)Style: CapsulesVerified PurchaseI will be updating this every few months.
Both my spouse and I have begun taking a Spore Probiotic.
I have two brands we are using. I am on the Youtheory.
My spouse is on Microbiome Labs MegaSporeBiotic. We are both
within normal weight range with 10 lbs to lose each, to put us at
Ideal weight within that same normal BMI.
1: One of us is SIBO gut challenged. I had been on PPI on and off,
and finally became compliant, to the point that small intestine bacterial
overgrowth occurred. What my doctor viewed as successful dosing, in
turn served me up a horrid gut imbalance. That, in under a year of
Compliance, so watch out if you are on PPI, the signs are bloating and
often a flip flop between constipation and diarrhea. It only seems mild
until it crosses the line to intolerable.
2: The other of us is pre-diabetic, cholesterol, early kidney challenged.
There are studies that note that B Subtilis may influence glucose transporters
to benefit those who have challenges, as well as other spores which
Influence cholesterol positively.
Spore probiotic have a long lifecycle and slowly colonize the GI tract.
They have a span of 3-4 weeks, compared to the 4-7 days of traditional
probiotics. A traditional probiotic has a low survival rate in arriving,
thus, more billions upon billions are required in dosage. Thus the smaller
dosage of Spore Probiotics which are 3 billion per capsule, is actually
superior to the many more billions of the traditional probiotics. That
said, smaller doses over time are the approach I am taking.
There are so many studies and for a great reason, all the evidence is
pointing to Spore Probiotics being beneficial.
Spore probiotics, being hardier and able to survive the voyage through your gut,
require a more watchful approach.
As many manufactures of Spore Probiotics state, start out slow and work
your way up to a larger dose. This makes perfect sense. That of course
does not factor in age related issues, health challenges, SIBO, IBS etc.
The last thing you want is to experience something (nausea, diarrhea,
fatigue, un-wellness) if indeed a different approach could have been taken.
So while die-off symptoms can be severe when they hit, working up
slowly in dose can negate much of that hardship!
That said, I forgot that rule of thumb and did the first week starting out
a touch quicker than I should have, before switching over to an every other
day regimen halfway through the week. What hit was a touch of not
feeling quite well, and taking a break from activities to recover.
The other person I simply started at 1 capsule, every third day, as I did
not want that person to experience any challenge. That person in
turn, did well with the first week.
Thus I kept to an every third day schedule for the first two weeks,
prior to graduating to every other day for the next two weeks.
At this dosage, the first month will not present the outcome of
regular use, but it will serve to ease us into this new probiotic without
much of the side effects of die off.
I will update this in a couple of months.
- Reviewed in the United States on March 16, 2025Size: 30 Count (Pack of 1)Style: GummiesVerified Purchasegreat product if you travel allot. Using a refrigerated pro-biotic is always best.
- Reviewed in the United States on March 30, 2025Size: 60 Count (Pack of 1)Style: CapsulesVerified PurchaseGood probiotic! A little pricey but very good!
- Reviewed in the United States on March 27, 2025Size: 180 Count (Pack of 1)Style: CapsulesVerified PurchaseThese spore Biotics are one of the best I’ve found.
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